What is estrogen?

Estrogens are a group of hormones that play an important role in the normal sexual and reproductive development in women. They are also sex hormones. The woman’s ovaries make most estrogen hormones, although the adrenal glands and fat cells also make small amounts of the hormones.

In addition to regulating the menstrual cycle, estrogen affects the reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, pelvic muscles, and the brain. Secondary sexual characteristics, such as pubic and armpit hair, also start to grow when estrogen levels rise. Many organ systems, including the musculoskeletal and cardiovascular systems, and the brain are affected by estrogen.

Hormone replacement therapy update

To learn more about women’s health, and specifically hormone replacement therapy, the National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH) started a large study in 1991 .It was called the Women’s Health Initiative (WHI). The hormone trial had two studies: the estrogen-plus-progestin (HRT) study of women with a uterus and the estrogen-alone (ERT) study of women without a uterus. Both studies were concluded early when the research showed that hormone replacement did not help prevent heart disease and it increased risk for some medical problems.

The FDA states that hormone therapy should not be taken to prevent heart disease.

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